Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma.

@article{Fung2006IncreasedEO,
  title={Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma.},
  author={K-M Fung and Eleni-Theano Samara and Chelsea C Wong and Ali Metwalli and Ryan M. Krlin and Barbara L Bane and Cheng Z Liu and J. T.-J. Yang and Jan V Pitha and Daniel J. Culkin and Bradley P. Kropp and Trevor M Penning and Hsueh-Kung Lin},
  journal={Endocrine-related cancer},
  year={2006},
  volume={13 1},
  pages={169-80}
}
Type 2 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) is a multi-functional enzyme that possesses 3alpha-, 17beta- and 20alpha-HSD, as well as prostaglandin (PG) F synthase activities and catalyzes androgen, estrogen, progestin and PG metabolism. Type 2 3alpha-HSD was cloned from human prostate, is a member of the aldo-keto reductase (AKR) superfamily and was named AKR1C3. In androgen target tissues such as the prostate, AKR1C3 catalyzes the conversion of Delta(4)-androstene-3,17-dione to… CONTINUE READING
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