Increased expression of transforming growth factor alpha precursors in acute experimental colitis in rats.

@article{Hoffmann1997IncreasedEO,
  title={Increased expression of transforming growth factor alpha precursors in acute experimental colitis in rats.},
  author={Phillip Hoffmann and J{\"o}rg M. Zeeh and Jayaraman Lakshmanan and V S Wu and Frank Procaccino and Max Reinshagen and J. A. Mcroberts and Viktor E. Eysselein},
  journal={Gut},
  year={1997},
  volume={41 2},
  pages={
          195-202
        }
}
BACKGROUND AND AIM Epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha), members of the EGF family of growth factors, protect rat gastric and colonic mucosa against injury. Having shown previously that exogenously applied EGF protects rat colonic mucosa against injury, the aim of the present study was to evaluate the endogenously expressed ligand mediating the protective effect of EGF/TGF-alpha in vivo. METHODS In an experimental model of trinitrobenzene sulphonic… CONTINUE READING

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