Increased expression of toll-like receptor 2 in rat diabetic nephropathy.

  title={Increased expression of toll-like receptor 2 in rat diabetic nephropathy.},
  author={Fanglin Li and Niansheng Yang and Lili Zhang and Hechang Tan and Bin Huang and Yingjie Liang and Miaoyan Chen and Xue-qing Yu},
  journal={American journal of nephrology},
  volume={32 2},
BACKGROUND/AIMS Inflammation is implicated in the pathogenesis of diabetic nephropathy (DN). This study examined the role of Toll-like receptor 2 (TLR2) in the progression of renal injury in a model of rat DN. METHODS DN was induced by intravenous injection of streptozotocin and rats were sacrificed at week 2, 4 and 8. Functional and pathologic markers, inflammatory infiltration, expression of TLR2, MCP-1, MyD88, HSP70, HMGB1 and activation of NF-kappaB were assessed. The effects of glucose… CONTINUE READING
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