Increased expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) in a more tumourigenic colon cancer cell line.

@article{Hewitt2000IncreasedEO,
  title={Increased expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) in a more tumourigenic colon cancer cell line.},
  author={Robert Edwin Hewitt and Kyle E. Brown and M. Corcoran and William G Stetler-Stevenson},
  journal={The Journal of pathology},
  year={2000},
  volume={192 4},
  pages={455-9}
}
Genetic changes occurring in the late stages of colonic tumour progression have received much less attention than those occurring in the early stages. As described in the accompanying paper, SW480 and SW620 cell lines provide a useful model for studying the advanced stages of progression for colon cancer. Comparison of the two cell lines by differential display reveals that SW620 cells express lower levels of the CC3 tumour suppressor gene and also lower levels of the tissue inhibitor of… CONTINUE READING

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