Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus.

@article{Popovic2005IncreasedEO,
  title={Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus.},
  author={Karin Popovic and Monica Ek and Alexander Espinosa and Leonid Padyukov and Helena Erlandsson Harris and Marie Wahren-Herlenius and Filippa Nyberg},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 11},
  pages={3639-45}
}
OBJECTIVE To investigate the role of the novel cytokine high mobility group box chromosomal protein 1 (HMGB-1) in the pathogenesis of cutaneous lupus erythematosus (CLE). METHODS Punch biopsy specimens of lesional and unaffected skin from 10 patients with CLE and 3 healthy control subjects were investigated. Immunohistochemical staining for HMGB-1, tumor necrosis factor alpha (TNFalpha), and interleukin-1beta (IL-1beta) was performed on consecutive sections. Analysis of single-nucleotide… CONTINUE READING

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