Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures.

@article{Akahoshi2007IncreasedEO,
  title={Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures.},
  author={Noriyuki Akahoshi and Yoshiya L. Murashima and Toshiyuki Himi and Yasuki Ishizaki and Isao Ishii},
  journal={Neuroscience letters},
  year={2007},
  volume={429 2-3},
  pages={136-41}
}
To examine lesions caused by seizures in the developing brain, seizures were induced by the intraperitoneal injection of kainate and nicotine into juvenile mice. After a week, whole brain sections were examined using histochemistry and the gene expression profiles in the neocortices and hippocampi were analyzed using a DNA microarray. Propidium iodide and Fluoro-Jade C staining revealed that kainate but not nicotine-induced degeneration of the hippocampal pyramidal neurons. Comparative analyses… CONTINUE READING
9 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…