Increased expression of the lipocalin 24p3 as an apoptotic mechanism for MK886.

  title={Increased expression of the lipocalin 24p3 as an apoptotic mechanism for MK886.},
  author={Zhimin Tong and Xuli Wu and James P. Kehrer},
  journal={The Biochemical journal},
  volume={372 Pt 1},
MK886, a strong proapoptotic agent, is an inhibitor of 5-lipoxygenase (LOX) through binding to the 5-LOX-activating protein (FLAP). Although MK886-induced apoptosis is through a FLAP-independent pathway, the precise mechanisms are not understood. In the present study, a possible role of 24p3, a lipocalin, in MK886-induced apoptosis was investigated. Exposure of murine prolymphoid progenitor cells (FL5.12) to 20 microM MK886 for 16 h dramatically increased 24p3 mRNA and protein expression… CONTINUE READING


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