Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury.

@article{Nadler2008IncreasedEO,
  title={Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury.},
  author={Yasmine Nadler and A. E. Alexandrovich and Nikolaos Grigoriadis and Tobias Hartmann and K. S. Jagannatha Rao and Esther Shohami and Reuven Stein},
  journal={Glia},
  year={2008},
  volume={56 5},
  pages={
          552-67
        }
}
Gamma-secretase is an aspartyl protease composed of four proteins: presenilin (PS), nicastrin (Nct), APH1, and PEN2. These proteins assemble into a membrane complex that cleaves a variety of substrates within the transmembrane domain. The gamma-secretase cleavage products play an important role in various biological processes such as embryonic development and Alzheimer's disease (AD). The major role of gamma-secretase in brain pathology has been linked to AD and to the production of the amyloid… CONTINUE READING
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