Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.

@article{Wong1987IncreasedEO,
  title={Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.},
  author={Albert J. Wong and Sandra H. Bigner and Darell D Bigner and Kenneth W. Kinzler and Stanley R. Hamilton and Bert Vogelstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 19},
  pages={6899-903}
}
Primary malignant gliomas from 63 patients were analyzed to determine the relationship between amplification of the gene encoding the epidermal growth factor receptor (EGFR) and expression of the corresponding mRNA. Twenty-four tumors were found to have amplified the EGFR gene and amplification of other genes occurred in three additional tumors. Hybridization with synthetic RNA probes was used to quantitate mRNA levels in situ. All 24 tumors with amplification of the EGFR gene had high levels… CONTINUE READING
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