Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: Effects of fluoxetine and MK-801

@article{Farley2012IncreasedEO,
  title={Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: Effects of fluoxetine and MK-801},
  author={S{\'e}verine Farley and Sylvie Dumas and Salah El Mestikawy and Bruno Giros},
  journal={Neuropharmacology},
  year={2012},
  volume={62},
  pages={503-517}
}

Figures from this paper

Both chronic treatments by epothilone D and fluoxetine increase the short‐term memory and differentially alter the mood status of STOP/MAP6 KO mice
TLDR
It is demonstrated that STOP KO mice could represent a useful model to study the relationship between cytoskeleton, mood, and stress, and to test innovative mood treatments, such as microtubule‐stabilizing compounds.
Differential expression of VGLUT3 in laboratory mouse strains: Impact on drug‐induced hyperlocomotion and anxiety‐related behaviors
TLDR
Investigation of strain differences in VGLUT3 expression levels and its potential correlates with anxiety and reward‐guided behaviors highlights the fact that one single gene polymorphism could not account for VGLut3 expression variations, and that region specific VGL UT3 expression level variations might play a key role in the modulation of discrete behaviors.
Changes in the Prefrontal Glutamatergic and Parvalbumin Systems of Mice Exposed to Unpredictable Chronic Stress
TLDR
It is hypothesized that chronic stress-induced enhancement of glutamatergic transmission in the PFC is a crucial contributing factor to changes within the prefrontal GABAergic and, specifically, PV system, and is associated with sex-specific changes in the mRNA expression of the NR2B subunit of the NMDA receptor.
Distribution of Aquaporin-4 channels in hippocampus and prefrontal cortex in mk-801-treated balb/c mice
TLDR
The distribution of AQP-4 channels in the prefrontal cortex and hippocampus in a mouse model of NMDA receptor blocking agent-induced schizophrenia-like behavior model and there was remarkable damage in neurons and glial cells is described.
...
...

References

SHOWING 1-10 OF 106 REFERENCES
Genetic Inactivation of the NMDA Receptor NR2A Subunit has Anxiolytic- and Antidepressant-Like Effects in Mice
TLDR
Results show a selective and robust reduction in anxiety- and depression-related behavior in NMDA receptor NR2A subunit KO mice, and provide insight into the role of glutamate in the pathophysiology and treatment of mood and anxiety disorders.
Evidence for increased expression of the vesicular glutamate transporter, VGLUT1, by a course of antidepressant treatment
TLDR
Immunoautoradiography analysis showed that repeated antidepressant drug treatment increased VGLUT1 protein expression, a key gene involved in the regulation of glutamate secretion, and data suggest that a course of antidepressant drug or ECS treatment increases expression of V GLUT1.
Blockade of CRF1 or V1b receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression
TLDR
Results point to an important role of CRF and AVP in the regulation of dentate neurogenesis, and suggest that CRF1 and V1b receptor antagonists may affect plasticity changes in the hippocampal formation, as do clinically effective antidepressants.
Corticolimbic Transcriptome Changes are State-Dependent and Region-Specific in a Rodent Model of Depression and of Antidepressant Reversal
TLDR
These studies established on a large-scale that the molecular impacts of antidepressants are region-specific and state-dependent, revealed common transcriptional changes downstream from different antidepressant treatments and supported CRF1 targeting as an effective therapeutic strategy.
...
...