Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation.

@article{Thimme2005IncreasedEO,
  title={Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation.},
  author={Robert Thimme and Victor Appay and Marie Koschella and Elisabeth Panther and Evelyn Roth and Andrew D Hislop and Alan B. Rickinson and Sarah L Rowland-Jones and H. E. Blum and Hanspeter Pircher},
  journal={Journal of virology},
  year={2005},
  volume={79 18},
  pages={12112-6}
}
The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by virus-specific T cells. We found that repetitive and persistent antigen stimulation leads to an increase in KLRG1 expression of virus-specific CD8+ T cells in mice and that virus-specific CD8+ T cells are mostly KLRG1+ in chronic human viral infections (human immunodeficiency virus, cytomegalovirus, and… CONTINUE READING

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