Increased expression of the MRP5 gene is associated with exposure to platinum drugs in lung cancer.

@article{Oguri2000IncreasedEO,
  title={Increased expression of the MRP5 gene is associated with exposure to platinum drugs in lung cancer.},
  author={Tetsuya Oguri and Takeshi Isobe and Takefumi Suzuki and Kazuto Nishio and Yasuhiro Fujiwara and Osamu Katoh and Michio Yamakido},
  journal={International journal of cancer},
  year={2000},
  volume={86 1},
  pages={95-100}
}
To investigate the role of the multidrug resistance-associated protein (MRP1) homologue MRP5 in relation to platinum drug resistance, we examined the steady-state levels of the mRNAs for MRP5 in both lung cancer cell lines and peripheral mononuclear cells (PMN) after exposure to platinum drug and in normal lung and lung cancer tissue specimens. Firstly, we examined MRP5 gene expression levels in 80 autopsy samples (40 primary tumors and 40 corresponding normal lung tissues) from 40 patients who… CONTINUE READING
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