Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis.

@article{Cravero2009IncreasedEO,
  title={Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis.},
  author={John D Cravero and Cathy S Carlson and Hee-Jeong Im and Raghunatha R Yammani and David L Long and Richard F. Loeser},
  journal={Arthritis and rheumatism},
  year={2009},
  volume={60 2},
  pages={492-500}
}
OBJECTIVE The chondrocyte response to insulin-like growth factor 1 (IGF-1) is reduced with aging and in osteoarthritis (OA). IGF-1 signals through the phosphatidylinositol 3-kinase/Akt pathway. TRB3, a tribbles homolog, has been shown to inhibit IGF-1-mediated activation of Akt in HEK 293 cells. This study was undertaken to determine if TRB3 is expressed in chondrocytes, and whether the chondrocyte response to IGF-1 is reduced by TRB3. METHODS Human articular cartilage was obtained from… CONTINUE READING
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