Increased expression of sodium channel subunit Nav1.1 in the injured dorsal root ganglion after peripheral nerve injury.

@article{Wang2011IncreasedEO,
  title={Increased expression of sodium channel subunit Nav1.1 in the injured dorsal root ganglion after peripheral nerve injury.},
  author={Wei Wang and Fidelis E. Atianjoh and Estelle B. Gauda and Myron Yaster and Yunqing Li and Yuan-Xiang Tao},
  journal={Anatomical record},
  year={2011},
  volume={294 8},
  pages={1406-11}
}
The mechanisms underlying neuropathic pain induction are very complex but might involve abnormal spontaneous activity in the sensory dorsal root ganglion (DRG). Voltage-gated sodium channels in the DRG are essential for the genesis of abnormal spontaneous neuronal activity. In this study, we examined the changes in expression of the voltage-gated sodium channel Nav1.1 in the DRG after peripheral nerve injury. Western blot analysis showed that the level of Nav1.1 protein in the ipsilateral L5… CONTINUE READING