Increased expression of receptor phosphotyrosine phosphatase-β/ζ is associated with molecular, cellular, behavioral and cognitive schizophrenia phenotypes

@inproceedings{Takahashi2011IncreasedEO,
  title={Increased expression of receptor phosphotyrosine phosphatase-β/ζ is associated with molecular, cellular, behavioral and cognitive schizophrenia phenotypes},
  author={Nagahide Takahashi and Takeshi Sakurai and Ozlem Bozdagi-Gunal and Nathan P Dorr and Jonathan Moy and Lee Krug and Miguel Gama-Sosa and Gregory A Elder and Rick J. Koch and Ruth H. Walker and Patrick R. Hof and Kenneth L. Davis and Joseph D. Buxbaum},
  booktitle={Translational Psychiatry},
  year={2011}
}
Schizophrenia is a serious and chronic mental disorder, in which both genetic and environmental factors have a role in the development of the disease. Neuregulin-1 (NRG1) is one of the most established genetic risk factors for schizophrenia, and disruption of NRG1 signaling has been reported in this disorder. We reported previously that NRG1/ErbB4 signaling is inhibited by receptor phosphotyrosine phosphatase-β/ζ (RPTP β/ζ) and that the gene encoding RPTPβ/ζ (PTPRZ1) is genetically associated… CONTINUE READING

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