Increased expression of protein kinase C beta activates ERK3.

  title={Increased expression of protein kinase C beta activates ERK3.},
  author={Samir Sauma and Eileen Friedman},
  journal={The Journal of biological chemistry},
  volume={271 19},
In a prior study, we have shown that stable transfection of expression plasmids for protein kinases C beta 1 (PKC beta 1) or PKC beta 2 into differentiated colon cancer cells led to elevated levels of PKC beta 1 or PKC beta 2 protein and PKC beta kinase activities in the transfectants, without altering PKC alpha levels. PKC gamma is not found in these cells, so the major modulation was in PKC beta. PKC beta transfectant cells exhibited blocked differentiation, increased growth rate in athymic… CONTINUE READING


Publications citing this paper.
Showing 1-9 of 9 extracted citations

Protein kinase C-mediated regulation of the cell cycle.

Frontiers in bioscience : a journal and virtual library • 2000

Similar Papers

Loading similar papers…