Increased expression of protease M in ovarian tumors.

  title={Increased expression of protease M in ovarian tumors.},
  author={Hirotoshi Tanimoto and Lowell J Underwood and Kazushi Shigemasa and Tim H Parmley and Timothy J O'brien},
  journal={Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine},
  volume={22 1},
Proteases are known to play important roles in tumor invasion and metastasis. Protease M, which was originally identified by Anisowicz and colleagues in 1996, is a new member of the serine protease family. We also identified the protease M transcript in a differential PCR screen of ovarian tumors and have investigated its expression in 44 ovarian tumors (12 low malignant potential tumors, 32 carcinomas) and 10 normal ovaries using quantitative PCR. The PCR product was labeled with (32)P and a… CONTINUE READING

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