Increased expression of prolactin receptor gene assessed by quantitative polymerase chain reaction in human breast tumors versus normal breast tissues.

@article{Touraine1998IncreasedEO,
  title={Increased expression of prolactin receptor gene assessed by quantitative polymerase chain reaction in human breast tumors versus normal breast tissues.},
  author={Philippe Touraine and Jvana Martini and Brigitte Zafrani and Jean Claude Durand and F Labaille and Catherine Malet and Andr{\'e} Victor Nicolas and Christine Trivin and Marie Catherine Postel-Vinay and Fr{\'e}d{\'e}rique Kuttenn and Paul A. T. Kelly},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1998},
  volume={83 2},
  pages={667-74}
}
The role of PRL in human breast tumorigenesis is not well understood. One of the limitations is the difficulty of accurately measuring PRL receptors (PRLR) in human tissues. We established a quantitative PCR method (Q-PCR) in T-47D human breast cancer cells and applied it to 29 patients, 25 of whom presented with either cancer or fibroadenoma. Four patients underwent a mammoplasty, and normal epithelial cells were cultured before Q-PCR. In T-47D cells, 31 x 10(6) messenger RNA molecules were… CONTINUE READING
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