Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers

@inproceedings{Liu2017IncreasedEO,
  title={Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers},
  author={Ying-xi Liu and Yiqian Cheng and Yun-fei Xu and Zhongtang Wang and Xianghao Du and Congcong Li and Jin Peng and Lu Gao and Xuanqiang Liang and Changsheng Ma},
  booktitle={Oncogene},
  year={2017}
}
Abnormal expression of activating/inhibitory receptors leads to natural killer (NK) cells dysfunction in tumor. Here we show that programmed cell death protein 1 (PD-1), a well-known immune checkpoint of T cells, is highly expressed on peripheral and tumor-infiltrating NK cells from patients with digestive cancers including esophageal, liver, colorectal, gastric and biliary cancer. The increased PD-1 expression on NK cells indicates poorer survival in esophageal and liver cancers. Blocking PD-1… CONTINUE READING

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