Increased expression of neuregulin-1 in differentiating muscle satellite cells and in motoneurons during muscle regeneration

@article{Hirata2007IncreasedEO,
  title={Increased expression of neuregulin-1 in differentiating muscle satellite cells and in motoneurons during muscle regeneration},
  author={Miyuki Hirata and Kunihiro Sakuma and Seiichiro Okajima and Hiroyoshi Fujiwara and Shuichiro Inashima and Masahiro Yasuhara and Toshikazu Kubo},
  journal={Acta Neuropathologica},
  year={2007},
  volume={113},
  pages={451-459}
}
Neuregulins belong to a family of multipotent growth-promoting proteins, and have been shown to have a crucial role in accumulating acetylcholine receptor at neuromuscular junctions. A functional role of neuregulins in muscle regeneration has not yet been identified. Using reverse transcription (RT)-PCR, Western blot and immunofluorescence analysis following bupivacaine injection into rat muscle, we investigated the expression pattern of neuregulin-1 (NRG-1) in normal and regenerating tibialis… CONTINUE READING