Increased expression of multidrug resistance-associated genes after chemotherapy in pediatric solid malignancies.

Abstract

BACKGROUND/PURPOSE The overexpression of multidrug resistance (MDR)-associated genes in primary untreated tumors has been proven to be associated with worse prognosis in various pediatric malignancies. This study compared the expression of 3 MDR-associated genes, MDR1, MDR-associated protein 1 (MRP1), and lung resistance-related protein (LRP), in pediatric… (More)
DOI: 10.1016/j.jpedsurg.2008.10.088

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