Increased expression of monocytic angiotensin-converting enzyme in dialysis patients with cardiovascular disease.

BACKGROUND Patients with chronic renal disease suffer from accelerated atherogenesis, which is promoted by inflammation and oxidative stress. Tissue angiotensin converting enzyme (ACE) exerts proinflammatory and prooxidative effects by producing angiotensin II. Monocytes are strongly involved in the pathogenesis of atherosclerosis. They express ACE, which… CONTINUE READING