Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas

  title={Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas},
  author={C{\'e}line Pinheiro and Adhemar Longatto-Filho and Cristovam Scapulatempo and Lu{\'i}sa Moares Nunes Ferreira and Sandra Marina Martins and Luc Pellerin and Mesquita Rodrigues and Ven{\^a}ncio Ferreira Avancini Alves and Fernando de Lander Schmitt and F{\'a}tima Baltazar},
  journal={Virchows Archiv},
Tumour cells are known to be highly glycolytic, thus producing high amounts of lactic acid. Monocarboxylate transporters (MCTs), by promoting the efflux of the accumulating acids, constitute one of the most important mechanisms in the maintenance of tumour intracellular pH. Since data concerning MCT expression in colorectal carcinomas (CRC) are scarce and controversial, the present study aimed to assess the expressions of MCT1, 2, and 4 in a well characterized series of CRC and assess their… CONTINUE READING
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