Increased expression of microRNA-148a in osteosarcoma promotes cancer cell growth by targeting PTEN

Abstract

Osteosarcoma is the most common type of primary malignant bone tumor, and deregulated microRNAs (miRNAs or miRs) in osteosarcoma have attracted great attention. In the present study, through miRNA microarray analysis, it was identified that miR-148a expression was significantly increased in osteosarcoma tissues. Increased miR-148a expression was significantly correlated with tumor progression and prognosis. Furthermore, increased miR-148a expression could promote osteosarcoma growth in vitro and in vivo, and the tumor-promoting effect was due to enhanced activation of the phosphoinositide 3-kinase signaling pathway caused by miR-148a-mediated inhibition of phosphatase and tensin homolog expression. Together, the present results suggest a role for miR-148a in osteosarcoma development and its potential use in prognosis prediction and cancer therapy.

6 Figures and Tables

Cite this paper

@inproceedings{Zhang2016IncreasedEO, title={Increased expression of microRNA-148a in osteosarcoma promotes cancer cell growth by targeting PTEN}, author={Hao Zhang and Yang Wang and Tianming Xu and Chen Li and Jiang Wu and Qianyun He and Guangchao Wang and Chen Ding and Kang Liu and Hao Tang and Fang Ji}, booktitle={Oncology letters}, year={2016} }