Increased expression of low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor in human malignant astrocytomas.

@article{Yamamoto1997IncreasedEO,
  title={Increased expression of low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor in human malignant astrocytomas.},
  author={Maeri Yamamoto and Kohichi Ikeda and Kohichi Ohshima and Hitoshi Tsugu and Hideki Kimura and Masamichi Tomonaga},
  journal={Cancer research},
  year={1997},
  volume={57 13},
  pages={2799-805}
}
Low-density lipoprotein receptor-related protein (LRP) plays an important role in regulating proteinase activity, which is necessary for cellular invasive processes. In this study, we investigated the presence of both LRP and urokinase-type plasminogen activator receptor (uPAR) in astrocytoma tissues and in glioma cell lines by PCR and immunohistochemical analysis. LRP mRNA was expressed frequently in glioblastomas, as compared with low-grade astrocytomas by PCR analysis and was well correlated… CONTINUE READING
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