Increased expression of interleukin 17 in inflammatory bowel disease

  title={Increased expression of interleukin 17 in inflammatory bowel disease},
  author={Sanae Fujino and Akira Andoh and Shigeki Bamba and Atsuhiro Ogaẃa and Kazunori Hata and Yoshio Araki and Tadao Bamba and Yoshihide Fujiyama},
  pages={65 - 70}
Background and aim: Interleukin (IL) 17 is a cytokine which exerts strong proinflammatory activities. In this study we evaluated changes in IL-17 expression in the inflamed mucosa and in the serum of patients with inflammatory bowel disease (IBD). Methods: Tissue samples were obtained endoscopically or surgically from patients with ulcerative colitis (UC) (n=20), Crohn’s disease (CD) (n=20), infectious colitis (n=5), ischaemic colitis (n=8), and normal colorectal tissues (n=15). IL-17… 

Differential regulation of interleukin 17 and interferon γ production in inflammatory bowel disease

A role for IL12, TGFβ and IL21 in modulating IL17/IFNγ production in IBD is supported, and the abundant IL17 in inflamed IBD mucosa may help explain the relative lack of efficacy of anti-IFnγ antibodies in clinical trials of Crohn’s disease.

Interleukin-17 Immunity in Pediatric Crohn Disease and Ulcerative Colitis

Activation of colonic IL-17/IL-22 axis and upregulation of FOXP3 to occur both in pediatric CD and in UC, indicating shared immunological characteristics.

Expression of Interleukin-26 is upregulated in inflammatory bowel disease

The results suggest that IL-26 plays a role in the pathophysiology of IBD through induction of inflammatory mediators.

Lipocalin-2 Is a Disease Activity Marker in Inflammatory Bowel Disease Regulated by IL-17A, IL-22, and TNF-&agr; and Modulated by IL23R Genotype Status

LowerLCN2 levels in CD patients carrying IBD risk–increasing IL23R variants may result from a restricted upregulation of LCN2 due to an impaired Th17 immune response, which proves to be a biomarker of active UC.

Interleukin 17 gene and protein expression are increased in patients with ulcerative colitis.

This is the first study to the best knowledge with a larger sample that explores IL-17 gene and protein expression from colonic biopsies in patients with ulcerative colitis (UC) and includes a healthy control group.

IL-23/IL-17A axis correlates with the nitric oxide pathway in inflammatory bowel disease: immunomodulatory effect of retinoic acid.

  • H. RafaH. Saoula C. Touil-Boukoffa
  • Biology, Medicine
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • 2013
The study indicates that the IL-23/IL-17A axis plays a pivotal role in IBD pathogenesis through the NO pathway, and shows that both p-STAT3 and inducible NOS expression was upregulated in PBMCs and colonic mucosa, especially in patients with active CD.

Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts.

IL-22 derived from activated T cells acts on SEMFs to elicit expression of proinflammatory cytokines and matrix-degrading molecules indicating proinflammatory/remodeling roles in IBD.

Expression and clinical significance of IL-17 and IL-17 receptor in ulcerative colitis

IL-17 levels were highly expressed in UC, especially in active phase, and correlated with CRP levels in UC patients, and it was concluded that the role of IL-17 in the patho-genesis of UC was explored.



Interleukin 16 expression and phenotype of interleukin 16 producing cells in Crohn's disease

Increased expression of IL-16 in T cells and mast cells in active Crohn's disease is associated with increased numbers of CD4+ lymphocytes, which seems to play a significant role in the initiation and persistence of the inflammatory process in Crohn’s disease.

Increased interleukin-17 production in patients with systemic sclerosis.

IL-17 overproduction plays an important role in the pathogenesis of SSc, especially in the early stages of the disease, by inducing the proliferation of fibroblasts and the production of IL-1 and the expression of adhesion molecules on endothelial cells.

IL-5 and TNF-α Participate in Recruitment of Eosinophils to Intestinal Mucosa in Ulcerative Colitis

In ulcerative colitis, eosinophils are attracted to the intestinal tissue by chemotactic factors, of which IL-5 and TNF-α may be the most prominent steroid-sensitive ones.

A role for IL-18 in intestinal inflammation?

There is considerable evidence that inflammatory bowel disease (IBD), and a variety of other inflammatory disorders, reflect an excessive Th1 response, and a number of studies depleting the known members of this inflammatory cascade have reported some “residual” pathology and suggested that “other mediators” may also be involved.

The Expression of IL-12 p40 and Its Homologue, Epstein-Barr Virus-Induced Gene 3, in Inflammatory Bowel Disease

EBI3 was significantly increased in both involved and uninvolved colonic mucosa in patients with UC and 5-aminosalicylic acid (5-ASA) use was significantly correlated with reduced IL-12 p40 levels in the patients with CD, but not in UC cases.

Tumor necrosis factor-alpha in serum of patients with inflammatory bowel disease as measured by a highly sensitive immuno-PCR.

Sensitive measurement of serum TNF-alpha could provide an important pathophysiologic marker for the presence and activity of IBD.

Up-Regulation of IL-17 Is Associated with Bioactive IL-8 Expression in Helicobacter pylori-Infected Human Gastric Mucosa1

Data indicate that biologically active IL-17 production is increased during Hp infection, suggesting the possibility that this cytokine may play an important role in the inflammatory response to the Hp colonization.

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

Increased numbers of IL-17 mRNA expressing MNC in MS are demonstrated with higher numbers in CSF than blood, and with the highest numbers in blood during clinical exacerbations.

Increased serum levels of eotaxin in patients with inflammatory bowel disease.

Eotaxin is significantly increased in serum of patients with active Crohn disease and ulcerative colitis, suggesting that this cytokine may play a role in the pathogenesis of IBD.

Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease.

Enhanced IL1-beta production from the inflamed mucosa may play an important role in the mediation of many inflammatory responses and is the result of a recruited population of cells.