Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival.

@article{Dai2003IncreasedEO,
  title={Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival.},
  author={Derek L. Dai and Nikita Makretsov and Eric I. Campos and Changzheng Huang and Youwen Zhou and David Huntsman and Madgalena Martinka and Gang Li},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2003},
  volume={9 12},
  pages={4409-14}
}
PURPOSE Integrin-linked kinase (ILK), a key component of the extracellular matrix adhesion, has been studied extensively in recent years. Overexpression of ILK in epithelial cells results in anchorage-independent cell growth with increased cell cycle progression. Furthermore, increased ILK expression is correlated with progression of several human tumor types, including breast, prostate, and colon carcinomas. However, the role of ILK overexpression in human melanoma pathogenesis is not known… CONTINUE READING

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