Increased expression of inducible nitric oxide synthase in psoriatic skin and cytokine-stimulated cultured keratinocytes.

@article{Sirsj1996IncreasedEO,
  title={Increased expression of inducible nitric oxide synthase in psoriatic skin and cytokine-stimulated cultured keratinocytes.},
  author={Allan Sirsj{\"o} and Marie Karlsson and Anders Gidl{\"o}f and Ola Rollman and Hans T{\"o}rm{\"a}},
  journal={The British journal of dermatology},
  year={1996},
  volume={134 4},
  pages={643-8}
}
Since nitric oxide (NO) has been implicated in the pathogenesis of various hyperproliferative and inflammatory diseases, the mRNA expression of constitutive nitric oxide synthase (cNOS) and inducible nitric oxide synthase (iNOS) were investigated in psoriatic skin by reverse transcriptase coupled to the polymerase chain reaction (PCR). The study showed that the mRNA expression of brain nitric oxide synthase (bNOS), one of two isoforms of cNOS, was weak in both psoriatic plaques lesions and… CONTINUE READING

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