Increased expression of hypoxia-inducible factor 1α in type I and type II endometrial carcinomas

  title={Increased expression of hypoxia-inducible factor 1α in type I and type II endometrial carcinomas},
  author={Vaishali Pansare and Adnan R. Munkarah and Veronica L Schimp and M. Arabi and Ghassan M. Saed and Robert J. T. Morris and Rouba Ali-Fehmi},
  journal={Modern Pathology},
Hypoxia-inducible factor 1α (HIF-1α) is a nuclear protein that is upregulated in many tumors and triggers biologic events intimately associated with aggressive tumor behavior. The aim of this study was to analyze the expression of HIF-1α, vascular endothelial growth factor (VEGF), Ki-67 and p53 in type I and type II endometrial adenocarcinoma. In total, 149 patients diagnosed with endometrial adenocarcinoma in our institute from 1995 to 2001 were included in this study, of which 108 were type I… CONTINUE READING
Highly Cited
This paper has 22 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 10 extracted citations

The role of hypoxia inducible factor-1alpha in gynecological cancer.

Critical reviews in oncology/hematology • 2011
View 6 Excerpts
Highly Influenced

Selected immunohistochemical prognostic factors in endometrial cancer.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society • 2010


Publications referenced by this paper.
Showing 1-10 of 29 references

The effect of cyclooxygenase-2 expression on tumor vascularity in advanced stage ovarian serous carcinoma

MC Rouba Ali-Fehmi, I Khalifeh, JM Malone
Cancer 2003;98:1423–1429 • 2003

Coexpression of hypoxia - inducible factors 1 a and 2 a , carbonic an - hydarse IX , and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survi

EP Hui, A Chan, F Pezella
Clin Cancer Res • 2002

Similar Papers

Loading similar papers…