Increased expression of heparanase in puromycin aminonucleoside nephrosis.

@article{Levidiotis2001IncreasedEO,
  title={Increased expression of heparanase in puromycin aminonucleoside nephrosis.},
  author={Vicki Levidiotis and John Kanellis and Francesco Libero Ierino and David A. Power},
  journal={Kidney international},
  year={2001},
  volume={60 4},
  pages={
          1287-96
        }
}
BACKGROUND The beta-D-endoglycosidase heparanase has been proposed as an important contributor to loss of glomerular charge in proteinuria. Expression of heparanase was, therefore, determined in acute puromycin aminonucleoside (PAN) nephrosis. METHODS A rabbit polyclonal antibody was produced against a 17-amino acid peptide derived from the predicted amino acid sequence of heparanase. The antibody was validated by Western blot. Immunohistochemical staining and Western blotting were used to… CONTINUE READING
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