Increased expression of dihydrodiol dehydrogenase induces resistance to cisplatin in human ovarian carcinoma cells.

@article{Deng2002IncreasedEO,
  title={Increased expression of dihydrodiol dehydrogenase induces resistance to cisplatin in human ovarian carcinoma cells.},
  author={Hong Bing Deng and Hemant K. Parekh and K-C Chow and Henry Simpkins},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 17},
  pages={
          15035-43
        }
}
We employed cDNA microarrays to identify the differentially expressed genes in a cisplatin-sensitive parental (2008) human ovarian carcinoma cell line and its cisplatin-resistant variant (2008/C13*). Differential expression of five genes was found in the 2008/C13* cells, a result confirmed by semi-quantitative reverse transcription-PCR. The five genes were identified as fibroblast muscle-type tropomyosin and skeletal muscle-type tropomyosin, dihydrodiol dehydrogenase, apolipoprotein J and… CONTINUE READING

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