Increased expression of cyclooxygenase-2 mediates enhanced contraction to endothelin ETA receptor stimulation in endothelial nitric oxide synthase knockout mice.

@article{Zhou2006IncreasedEO,
  title={Increased expression of cyclooxygenase-2 mediates enhanced contraction to endothelin ETA receptor stimulation in endothelial nitric oxide synthase knockout mice.},
  author={Yingbi Zhou and Srabani Mitra and Saradhadevi Varadharaj and Narasimham L. Parinandi and Jay L. Zweier and Nicholas A Flavahan},
  journal={Circulation research},
  year={2006},
  volume={98 11},
  pages={1439-45}
}
The aim of this study was to determine whether prolonged loss of NO activity, in endothelial NO synthase knockout (eNOS(-/-)) mice, influences endothelin (ET) ETA receptor-mediated smooth muscle contraction and, if so, to define the underlying mechanism(s). In isolated endothelium-denuded abdominal aortas, contractions to the selective ETA receptor agonist ET-1(1-31) were significantly increased in aortas from eNOS(-/-) compared with wild-type (WT) mice. In contrast, contractions to the alpha1… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 47 references

Vasoactive prostanoids are generated from arachidonic acid by COX-1 and COX-2 in the mouse.

American journal of physiology. Heart and circulatory physiology • 2005
View 10 Excerpts
Highly Influenced

Prevention of endothelin-1-induced increases in blood pressure: role of endogenous CGRP.

American journal of physiology. Heart and circulatory physiology • 2004
View 10 Excerpts
Highly Influenced

Say NO to ET.

Journal of the autonomic nervous system • 2000
View 10 Excerpts
Highly Influenced

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