Increased expression of cyclooxygenase-2 in human pancreatic islets treated with high glucose or ligands of the advanced glycation endproduct-specific receptor (AGER), and in islets from diabetic mice

Abstract

The cyclooxygenase-2 (PTGS2, previously known as COX2) enzyme and its products, such as prostaglandin E2 (PGE2), have been implicated in the pathogenesis of several inflammatory diseases including islet dysfunction under diabetic conditions. In this study we evaluated whether diabetic conditions in vitro, such as high-glucose (HG) culture or AGE, or in vivo… (More)
DOI: 10.1007/s00125-005-0065-7

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