Increased expression of cyclin-dependent kinase 5 in induced apoptotic neuron death in rat substantia nigra.

@article{Henchcliffe1997IncreasedEO,
  title={Increased expression of cyclin-dependent kinase 5 in induced apoptotic neuron death in rat substantia nigra.},
  author={Claire Henchcliffe and Robert E Burke},
  journal={Neuroscience letters},
  year={1997},
  volume={230 1},
  pages={41-4}
}
We reported previously that striatal excitotoxic lesion with quinolinic acid of rat pups during the first 2 weeks of postnatal life results in loss of dopaminergic neurons of the substantia nigra (SN) due to induced apoptosis. Here we demonstrate by immunohistochemistry that, following such a lesion, high levels of cyclin-dependent kinase 5 (cdk5) protein are present exclusively in apoptotic cells over and above basal levels of diffuse axonal staining. Furthermore, localization of high levels… CONTINUE READING
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