Increased expression of cyclin D1 in a murine mammary epithelial cell line induces p27kip1, inhibits growth, and enhances apoptosis.

Abstract

Cyclin D1 is frequently amplified and/or overexpressed in human breast cancer and several other types of cancer. To examine the role of cyclin D1 in normal mammary epithelial cells, in the present study we have overexpressed human cyclin D1 in the mouse mammary epithelial cell line HC11, using retrovirus-mediated transduction. We found that the cyclin D1… (More)

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@article{Han1996IncreasedEO, title={Increased expression of cyclin D1 in a murine mammary epithelial cell line induces p27kip1, inhibits growth, and enhances apoptosis.}, author={Edward Kyu-ho Han and Matthias Begemann and Alessandro Sgambato and J W Soh and Yuichiro Doki and W Q Xing and W Liu and I. Bernard Weinstein}, journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research}, year={1996}, volume={7 6}, pages={699-710} }