Increased expression of caveolin-1 in heterozygous Niemann-Pick type II human fibroblasts.

@article{Garver1997IncreasedEO,
  title={Increased expression of caveolin-1 in heterozygous Niemann-Pick type II human fibroblasts.},
  author={William S. Garver and Shu-Hsuan Hsu and Robert P. Erickson and Wenda L. Greer and David M. Byers and Randall A. Heidenreich},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={236 1},
  pages={189-93}
}
Human Niemann-Pick type II fibroblasts, which encompass the panethnic type C (NPC) and Nova Scotia Acadian type D (NPD) variants, exhibit altered expression of caveolin-1 protein when examined by immunoblotting using an anti-caveolin-1 monoclonal antibody. Unexpectedly, caveolin-1 in heterozygous fibroblasts was significantly elevated as much as 10-fold… CONTINUE READING