Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa.

@article{Usui2009IncreasedEO,
  title={Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa.},
  author={Shinichi Usui and Keiichi Komeima and Sun Young Lee and Young-Joon Jo and Shinji Ueno and Brian S Rogers and Zhihao Wu and Jikui Shen and Lili Lu and Brian C. Oveson and Peter S. Rabinovitch and Peter A Campochiaro},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2009},
  volume={17 5},
  pages={778-86}
}
Oxidative and nitrosative damage are major contributors to cone cell death in retinitis pigmentosa (RP). In this study, we explored the effects of augmenting components of the endogenous antioxidant defense system in models of RP, rd1, and rd10 mice. Unexpectedly, overexpression of superoxide dismutase 1 (SOD1) in rd1 mice increased oxidative damage and accelerated cone cell death. With an elaborate mating scheme, genetically engineered rd10 mice with either inducible expression of SOD2… CONTINUE READING

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