Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas.

@article{Hinoshita2000IncreasedEO,
  title={Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas.},
  author={Eiji Hinoshita and Takeshi Uchiumi and Ken-ichi Taguchi and Naoko Kinukawa and Masazumi Tsuneyoshi and Yoshihiko Maehara and Keishi Sugimachi and Mitsuhiro Kuwano},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2000},
  volume={6 6},
  pages={
          2401-7
        }
}
The expression of ATP-binding cassette superfamily transporter genes, such as P-glycoprotein/multidrug resistance (MDR) 1 and MDR protein (MRP) 1, is often up-regulated in various tumor types and is involved in responses to some anticancer chemotherapeutic agents. Five human MRP subfamily members (MRP2-6) with structural similarities to MRP1 have been identified. The relationships between MRP2-6 mRNA levels and drug resistance are not well understood. Data on 45 patients with colorectal cancer… CONTINUE READING

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