Increased expression of adrenomedullin mRNA in the tissues of intraocular and orbital tumors.

Abstract

PURPOSE To explore the possible involvement of adrenomedullin in the pathophysiology of intraocular and orbital tumors. METHODS Competitive reverse transcription-polymerase chain reaction was used to determine adrenomedullin mRNA levels in the tissues from 40 consecutive patients (40 eyes) undergoing vitrectomy, orbital tissue biopsy, or enucleation for various ocular diseases, including intraocular (n = 4) and orbital (n = 3) tumors, proliferative vitreoretinopathy (n = 8), proliferative diabetic retinopathy (n = 8), age-related macular degeneration (n = 4), preretinal macular fibrosis (n = 9), and acute retinal necrosis (n = 4). RESULTS Adrenomedullin mRNA levels in the tissues obtained from patients with intraocular or orbital tumors were significantly higher than those of patients with proliferative vitreoretinopathy (P <.05), proliferative diabetic retinopathy (P <.05), preretinal macular fibrosis (P <.005), and acute retinal necrosis (P <.01). CONCLUSION Adrenomedullin may play a role in the pathophysiology of intraocular and orbital tumors.

Cite this paper

@article{Udono2000IncreasedEO, title={Increased expression of adrenomedullin mRNA in the tissues of intraocular and orbital tumors.}, author={Tetsuo Udono and Kazuhito Totsune and Kentaro Takahashi and Toshiaki Abe and Masaaki Sato and Shigeki Shibahara and Makoto Tamai}, journal={American journal of ophthalmology}, year={2000}, volume={129 4}, pages={555-6} }