Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease.

@article{Szebeni2008IncreasedEO,
  title={Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease.},
  author={Be{\'a}ta Szebeni and G{\'a}bor Veres and Antal Dezsőfi and Krisztina Szilvia Rusai and {\'A}d{\'a}m Vannay and Mark Mraz and E Majorov{\'a} and Andr{\'a}s Arat{\'o}},
  journal={Clinical and experimental immunology},
  year={2008},
  volume={151 1},
  pages={34-41}
}
Inflammatory bowel disease (IBD) may result from exaggerated stimulation of the mucosal immune system by luminal bacterial flora. Bacterial products are recognized by pattern recognition receptors such as Toll-like receptors (TLRs), which are key regulators of the innate immune system. Therefore, the expression of TLR2, TLR3 and TLR4 in colonic biopsy samples taken from children with active IBD were studied and compared to controls. Colonic biopsy samples were collected from macroscopically… CONTINUE READING

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