Increased expression of Slug and Vimentin as novel predictive biomarkers for lymph node metastasis and poor prognosis in colorectal cancer.

@article{Toiyama2013IncreasedEO,
  title={Increased expression of Slug and Vimentin as novel predictive biomarkers for lymph node metastasis and poor prognosis in colorectal cancer.},
  author={Yuji Toiyama and Hiromi Yasuda and Susumu Saigusa and Koji Tanaka and Yasuhiro Inoue and Ajay Goel and Masato Kusunoki},
  journal={Carcinogenesis},
  year={2013},
  volume={34 11},
  pages={2548-57}
}
Slug and Vimentin genes play a critical role in regulating epithelial-mesenchymal transition (EMT) via downregulation of epithelial markers and upregulation of mesenchymal markers. The present study evaluated the clinical significance of Slug and Vimentin expression as potential disease biomarkers in colorectal cancer (CRC). At first, the biological role of Slug in CRC was assessed by RNA interference in CRC cell lines to assess tumor progression, invasion and migration. Next, we analyzed Slug… CONTINUE READING