Increased expression of SERCA in the hearts of transgenic mice results in increased oxidation of glucose.

@article{Belke2007IncreasedEO,
  title={Increased expression of SERCA in the hearts of transgenic mice results in increased oxidation of glucose.},
  author={Darrell D. Belke and Eric Swanson and Jaime Su{\'a}rez and Brian T. Scott and Antine E. Stenbit and Wolfgang H. Dillmann},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={292 4},
  pages={H1755-63}
}
While several transgenic mouse models exhibit improved contractile characteristics in the heart, less is known about how these changes influence energy metabolism, specifically the balance between carbohydrate and fatty acid oxidation. In the present study we examine glucose and fatty acid oxidation in transgenic mice, generated to overexpress sarco(endo)plasmic reticulum calcium-ATPase (SERCA), which have an enhanced contractile phenotype. Energy substrate metabolism was measured in isolated… CONTINUE READING
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