Increased expression of Na+/H+ exchanger isoform 1 predicts tumor aggressiveness and unfavorable prognosis in epithelial ovarian cancer

@inproceedings{Wang2018IncreasedEO,
  title={Increased expression of Na+/H+ exchanger isoform 1 predicts tumor aggressiveness and unfavorable prognosis in epithelial ovarian cancer},
  author={Haixia Wang and Xingtao Long and Dong Wang and Meng Lou and Dongling Zou and Rui Chen and Weiqi Nian and Qi Zhou},
  booktitle={Oncology letters},
  year={2018}
}
Na+/H+ exchanger isoform 1 (NHE1), which is a regulator of intracellular and extracellular pH via ion exchange, has been demonstrated to serve an important role in cell differentiation, migration and invasion in solid tumors and hematological malignancies. However, the potential role of NHE1 in epithelial ovarian cancer (EOC) remains unclear. In the present study, the expression pattern and the prognostic value of NHE1 were investigated in EOC. EOC tissues, non-cancerous tumors and normal… CONTINUE READING

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