Increased expression of MDR1 mRNAs and P-glycoprotein in placentas from HIV-1 infected women.

@article{Camus2006IncreasedEO,
  title={Increased expression of MDR1 mRNAs and P-glycoprotein in placentas from HIV-1 infected women.},
  author={Mathieu Camus and Claudine Delom{\'e}nie and Nathalie Didier and Albert Faye and Sophie Gil and M-C Dauge and Alo{\"i}se M Mabondzo and Robert Farinotti},
  journal={Placenta},
  year={2006},
  volume={27 6-7},
  pages={699-706}
}
P-glycoprotein transports several compounds including protease inhibitors, actually used in the clinical management of HIV-1 infection. Since P-glycoprotein is expressed in placental trophoblasts, its efflux activity could interfere with placental transfer of antiretrovirals. The purpose of this study was to investigate the expression of P-gp-encoding MDR1 gene and P-gp itself in full-term placentas from uninfected (n=35) and HIV-1 infected women (n=24). MDR1 transcripts were quantified by real… CONTINUE READING

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