Increased expression of IRS-1 is associated with lymph node metastasis in nasopharyngeal carcinoma.

@article{Luo2014IncreasedEO,
  title={Increased expression of IRS-1 is associated with lymph node metastasis in nasopharyngeal carcinoma.},
  author={Jiadi Luo and Qiuyuan Wen and Jiao Li and Lina Xu and Shuzhou Chu and Weiyuan Wang and Lei Shi and Guiyuan Xie and Donghai Huang and Songqing Fan},
  journal={International journal of clinical and experimental pathology},
  year={2014},
  volume={7 9},
  pages={6117-24}
}
Nasopharyngeal carcinoma (NPC) is a head and neck malignant tumor rare throughout most of the world but common in Southeast Asia, especially in Southern China, which is with characteristics of early cervical lymph node metastasis and high incidence rate of distant metastasis. Insulin receptor substrate 1 (IRS-1) is a signaling adapter protein that is encoded by the IRS-1 gene in humans, plays an important role in the development, progression, invasion and metastasis of tumors. The aim of the… CONTINUE READING

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lymph nodesIs associated anatomic site oflymph node metastases
Taken together , high expression of IRS-1 might be closely correlated with lymph node metastasis in NPC and positive expression of IRS-1 could be used as an independent biomarker for predicting lymph node metastasis of NPC .
The positive percentage of IRS-1 expression in NPC with lymph node metastasis was also significantly higher than those without lymph node metastasis ( P = 0.008 ) .
The positive percentage of IRS-1 expression in NPC with lymph node metastasis was also significantly higher than those without lymph node metastasis ( P = 0.008 ) .
Taken together , high expression of IRS-1 might be closely correlated with lymph node metastasis in NPC and positive expression of IRS-1 could be used as an independent biomarker for predicting lymph node metastasis of NPC .
lymph nodesIs metastatic anatomic site of diseaselymph node metastases
Taken together , high expression of IRS-1 might be closely correlated with lymph node metastasis in NPC and positive expression of IRS-1 could be used as an independent biomarker for predicting lymph node metastasis of NPC .
The positive percentage of IRS-1 expression in NPC with lymph node metastasis was also significantly higher than those without lymph node metastasis ( P = 0.008 ) .
The positive percentage of IRS-1 expression in NPC with lymph node metastasis was also significantly higher than those without lymph node metastasis ( P = 0.008 ) .
Taken together , high expression of IRS-1 might be closely correlated with lymph node metastasis in NPC and positive expression of IRS-1 could be used as an independent biomarker for predicting lymph node metastasis of NPC .
Insulin receptor substrate 1 ( IRS-1 ) is a signaling adapter protein that is encoded by the IRS-1 gene in humans , plays an important role in the development , progression , invasion and metastasis of tumors .
Insulin receptor substrate 1 ( IRS-1 ) is a signaling adapter protein that is encoded by the IRS-1 gene in humans , plays an important role in the development , progression , invasion and metastasis of tumors .
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