Increased expression of HIP/PAP and regenerating gene III in human inflammatory bowel disease and a murine bacterial reconstitution model.

@article{Ogawa2003IncreasedEO,
  title={Increased expression of HIP/PAP and regenerating gene III in human inflammatory bowel disease and a murine bacterial reconstitution model.},
  author={Hitoshi Ogawa and Kouhei Fukushima and Hiroo Naito and Yuji Funayama and Michiaki Unno and Ken-ichi Takahashi and Taku Kitayama and Seiki Matsuno and Haruo Ohtani and Shin Takasawa and Hiroshi Okamoto and Iwao Sasaki},
  journal={Inflammatory bowel diseases},
  year={2003},
  volume={9 3},
  pages={
          162-70
        }
}
Although microorganisms play a role in gut inflammation, it remains uncertain which epithelial genes are expressed in response to luminal flora and whether these molecules are also involved in pathologic mucosal inflammation. Germ-free mice were orally challenged with a bacterial suspension prepared from conventionally housed mice (bacterial reconstitution). Thereafter, the differential gene expression in gut epithelial cells was identified by differential display. The expression of the… CONTINUE READING
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