Increased expression of Gi alpha 2 in mouse embryo stem cells promotes terminal differentiation to adipocytes.

@article{Su1993IncreasedEO,
  title={Increased expression of Gi alpha 2 in mouse embryo stem cells promotes terminal differentiation to adipocytes.},
  author={H L Su and Craig C. Malbon and H y Wang},
  journal={The American journal of physiology},
  year={1993},
  volume={265 6 Pt 1},
  pages={C1729-35}
}
The level of Gs alpha activity has been shown to modulate the rate of adipogenesis in mouse embryo fibroblast 3T3-L1 cells (H.-Y. Wang, D. C. Watkins, and C. C. Malbon. Nature Lond. 358: 334-337, 1992). For the current work the role of Gi alpha 2, a G protein mediator of inhibitory control of adenylyl cyclase, in regulating terminal differentiation of these cells was explored by stable transfection of fibroblasts expressing wild-type and a constitutively active mutant of Gi alpha 2 (Q205L… CONTINUE READING

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