Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs

@inproceedings{Bloch2015IncreasedEO,
  title={Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs},
  author={Susannah A A Bloch and Jen Y. Lee and Thomas Syburra and Ulrich Peter Rosendahl and Mark J. D. Griffiths and Paul R Kemp and Michael Ian Polkey},
  booktitle={Thorax},
  year={2015}
}
RATIONALE The molecular mechanisms underlying the muscle atrophy of intensive care unit-acquired weakness (ICUAW) are poorly understood. We hypothesised that increased circulating and muscle growth and differentiation factor-15 (GDF-15) causes atrophy in ICUAW by changing expression of key microRNAs. OBJECTIVES To investigate GDF-15 and microRNA expression in patients with ICUAW and to elucidate possible mechanisms by which they cause muscle atrophy in vivo and in vitro. METHODS In an… CONTINUE READING
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