Increased expression of Ca2+-sensitive K+ channels in the cerebral microcirculation of genetically hypertensive rats: evidence for their protection against cerebral vasospasm.

@article{Liu1998IncreasedEO,
  title={Increased expression of Ca2+-sensitive K+ channels in the cerebral microcirculation of genetically hypertensive rats: evidence for their protection against cerebral vasospasm.},
  author={Y Liu and Antal G. Hudetz and Hans Guenther Knaus and Nancy J. Rusch},
  journal={Circulation research},
  year={1998},
  volume={82 6},
  pages={
          729-37
        }
}
The Ca2+-sensitive K+ channel (K(Ca) channel) plays a key role in buffering pressure-induced constriction of small cerebral arteries. An amplified current through this channel has been reported in vascular smooth muscle cells obtained from hypertensive animals, implying that the expression or properties of K(Ca) channels may be regulated by in vivo blood pressure levels. In this study, we investigated this hypothesis and its functional relevance by comparing the properties, expression levels… CONTINUE READING

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