Increased expression of CRF and CRF-receptors in dorsal striatum, hippocampus, and prefrontal cortex after the development of nicotine sensitization in rats.

@article{Carboni2018IncreasedEO,
  title={Increased expression of CRF and CRF-receptors in dorsal striatum, hippocampus, and prefrontal cortex after the development of nicotine sensitization in rats.},
  author={Lucia Carboni and Benedetto Romoli and Simon T. Bate and Patrizia Romualdi and Michele Zoli},
  journal={Drug and alcohol dependence},
  year={2018},
  volume={189},
  pages={
          12-20
        }
}
BACKGROUND Nicotine addiction supports tobacco smoking, a main preventable cause of disease and death in Western countries. It develops through long-term neuroadaptations in the brain reward circuit by modulating intracellular pathways and regulating gene expression. This study assesses the regional expression of the transcripts of the CRF transmission in a nicotine sensitization model, since it is hypothesised that the molecular neuroadaptations that mediate the development of sensitization… CONTINUE READING